Introduction to Bioinformatics: CMSC54610-1, Winter Quarter 2007.

Lecture 8: Genomics and Gene Recognition

  • Prokaryotic Genomes: Table 6.1 gives examples
  • Prokaryotic Gene Structure
  • GC content in Prokaryotic Genomes: varies betwen 1/4 and 3/4
  • Prokaryotic Gene Density: 950 bp coding, 118 bp filler average for E. coli
  • Eukaryotic Genomes: Table 6.3 gives examples
  • Eukaryotic Gene Structure and Open reading frames
  • GC content in Eukaryotic Genomes
  • Gene Expression: SAGE and Microarrays
  • DNA microarrays
  • DNA archeology
  • SAGE and GLGI
  • bioinfo payoff: fixing the record, cf.
  • relation to matching contigs in shotgun sequencing
  • homework problems