Introduction to Bioinformatics: CMSC54610-1, Winter Quarter 2007.

Lecture 8: Genomics and Gene Recognition

• GC content in eukaryotics
  • CpG islands
  • density of CpG indicates coding region
  • Cytosine methylation forms 5-methylcytosine
    • makes C more like the others (12->15 atoms): recall the structure of DNA from the first lecture
    • oxidative deamination changes meth-C to T
  • Cromatin at Wikipedia and the Cromatin network
    • histone proteins
    • epigenetic factors: do not cite this

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